Research Paper: Multiplex, Single Step, On Chip Detection of Mutation in Circulating Tumor DNA



I did all the CAD and simulation work for this project. My largest roles were flow and temperature cycle balancing, device usability design, and FEA simulations. The device detects the presence of four different cancer treatment response markers in under half an hour using the patient’s blood. It is also handheld and portable, with a replaceable chip inside a reusable detector shell. The results of the device give important insight into which cancer treatments will be effective, in this case specifically for non-small cell lung cancer.




Here is the presentation for the device:

 Final Presentation PDF


And the research paper I wrote on the simulations and calculations I made.